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My lab is the first to demonstrate full-length optic nerve regeneration in post born mice, and moreover, discover the molecules that can awaken the "sleeping" retinal progenitor cells to repair the retina.
These works hold a promise not only for restoring sight to people with retinal or optic nerve damage or diseases, but similarly to repair spinal cord or brain injuries. My expertise in retinal biology, retinal injury response, and neuroretinal repair and regeneration has contributed critically to the knowledge and design of therapeutics for blind-causing retinal diseases and for overcoming the key barriers to restore vision.
Our work was published in Cell, Nature, Science, Neuron, Nature Neuroscience and so forth. I am pay day loans Editorial Board Member of Stem Cells, Neural Regeneration Research, and Asia-Pacific Journal of Ophthalmology, and a member of the Scientific Advisory Board of New Jersey Commission on Brain Pay day loans.
I was awarded with Visiting Professorship at the New York Eye and Ear Infirmary in 2008 and an RPB Sybil B. I was a recipient of Outstanding Scientific Achievement Award from RP International. Schepens Eye Research Institute, Harvard Medical SchoolPurpose: The development of a suitable storage method for retinal pigment epithelium (RPE) is necessary in the establishment of future RPE replacement therapy, and storage temperature has proven to be pivotal for cell survival.
In this study, we analyze the gene expression profile of cultured ARPE-19 cells after seven days of storage at different temperatures in an effort to predict the gene-level consequences of storage of RPE transplants. The total RNA was isolated and the gene expression profile was determined using DNA microarrays.
The Results were validated using qPCR. Results: Principal component and hierarchical clustering analyses show that the gene expression profiles of cell cultures stored at different temperatures cluster into separate groups. There was no evidence of the activation of inflammatory processes in stored cell cultures.
Abstract Evolving research has provided evidence that noninvasive electrical stimulation (ES) of the eye may be a promising therapy for either preserving or restoring vision in several retinal and optic nerve diseases. In this review, we focus on minimally invasive strategies for the delivery of ES and accordingly summarize the current literature on transcorneal, transorbital, and transpalpebral ES in both animal experiments and clinical studies.
Various mechanisms are believed to underlie the effects of ES, including increased production of cash loans neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cytokines. Different animal models have demonstrated favorable effects of ES on both the retina and the optic nerve. There is thus a pressing need for a deeper understanding of the underlying mechanisms that govern clinical success and optimization of stimulation parameters in animal studies.
In addition, such research should be followed by large, prospective, clinical studies to explore the full potential of ES. Through this review, we aim to provide insight to guide future research on ES as a potential therapy for improving vision. View all works in CristinDomus Odontologica Building A1 RH, M-floor (map) Sognsvannsveien 10 0372 OSLO NorgeP. Impact of Storage Temperature on the Expression of Cell cash loans Survival Genes in Cultured ARPE-19 Cells.
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